AUTO-IMMUNE RESPONSE TO NUCLEUS PULPOSUS IN THE RABBIT
نویسندگان
چکیده
منابع مشابه
Primary immune system responders to nucleus pulposus cells: evidence for immune response in disc herniation.
Although intervertebral disc herniation and associated sciatica is a common disease, its molecular pathogenesis is not well understood. Immune responses are thought to be involved. This study provides direct evidence that even non-degenerated nucleus pulposus (NP) cells elicit immune responses. An in vitro colony forming inhibition assay demonstrated the suppressive effects of autologous spleen...
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STUDY DESIGN Asymptomatic volunteers underwent magnetic resonance imaging to investigate how different positions affect lumbar intervertebral discs. OBJECTIVE To quantify sagittal migration of the lumbar nucleus pulposus in 6 functional positions. SUMMARY OF BACKGROUND DATA Previous studies of the intervertebral disc response in the sagittal plane were limited to imaging of recumbent positi...
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Introduction: Although formalin-induced activity in primary afferent fibers and spinal dorsal horn is well described, the midbrain neural basis underlying each phase of behavior in formalin test has not been clarified. The present study was designed to investigate the nucleus cuneiformis (CnF) neuronal responses during two phases after subcutaneous injection of formalin into the hind paw...
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BACKGROUND Earlier work has suggested that the p38 MAPK, JNK1/2 and ERK1/2 signal pathway existed in nucleus pulposus cells and the cell growth, differentiation and apoptosis were regulated by them. Because osmotic fluctuations are inevitable in the physicochemical environment of intervertebral disc cells, high osmolality could activate p38 MAPK, JNK1/2 and ERK1/2 signal pathway. The effects of ...
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Many of the therapeutic interventions for intervertebral disc degeneration attempt to repopulate the nucleus pulposus (NP) tissue; however, NP cells are heterogeneous and not well characterized. To address this, we have investigated the morphology, extracellular gene and protein expression, and apoptosis changes in NP explants cultured in vitro with or without chondrogenic reagents for differen...
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ژورنال
عنوان ژورنال: The Journal of Bone and Joint Surgery. British volume
سال: 1965
ISSN: 0301-620X,2044-5377
DOI: 10.1302/0301-620x.47b3.574